Canadian Human and Statistical Genetics Meeting

April 29 – May 2, 2012

Program

Track 1 Genetic Epidemiology/Population Genetics

Track 2 Human Genetics

Day 1
Day 2
Day 3
Day 4

Sunday 29 April
Time	Session	Location
14:00 - 18:00	Check-in and Poster set-up Poster set up in Studios 10 and 11	Concourse Level
18:00 - 20:00	Dinner	Sunhill Dining Room
20:00 - 20:10	Conference Opening Welcome by Conference Co-Chairs Dr. Jayne Danska and Dr. Erwin Schurr Welcome by Mr. Chris Wagner, Canadian Gene Cure Foundation Board Member
20:10 - 21:30	Plenary Session on Infectious Disease Chair: Erwin Schurr (McGill University) Genetic effects in Infectious Diseases: from Mice to Humans Philippe Gros (McGill University) Toward a genetic theory of infectious diseases Jean-Laurent Casanova (Rockefeller University) An ENU-Induced Mutation in STAT4 Increases Innate Susceptibility to Acute Salmonella Typhimurium Infection in Mice Megan Eva (McGill University) Evolutionary Genetic Dissection of Human Interferons Jeremy Manry (McGill University Health Center) Evaluate this session	Grand Event Room A&B

Monday 30 April
Time	Session	Location
7:30 - 8:30	Breakfast	Sunhill Dining Room
8:30 - 10:00 Track 1	Topics in Genetic Epidemiology and Statistical Genetics Sponsored by Fields Chair: Shelley Bull (University of Toronto) Prioritized-GWAS Based on Linkage Information Identifies Novel Putative Loci Influencing Coagulation France Gagnon (University of Toronto) Statistical Methods and Strategies for Integrative Data Analysis Joseph Beyene (McMaster University) DMap: A New Method to Fine Map a Complex Trait via the Ancestral Recombination Graph Marie-Hélène Descary (Université du Québec à Montréal) Joint Modelling of the Disease and Endophenotype to Characterize Genes Effects and their Interactions Moliere Nguile (Centre de Recherche Université Laval Robert Giffard) On the Analysis of Imputed Genotypes in Family-Based Association Studies Aurelie Cobat (McGill University) Evaluate this session	Grand Event Room A&B
8:30 - 10:00 Track 2	Animal Model Session 1 Chair: Jayne Danska (Hospital for Sick Children, University of Toronto) Fishing for causes and cures of neurodegeneration Pierre Drapeau () Cell Polarity in Flies Helen McNeill (Mt Sinai Hospital) Mouse ENU mutagenesis to understand gene function during inflammatory and immune responses against pathogens Silvia Vidal (McGill University) Evaluate this session	Amphitheatre
10:00 - 10:30	Break
10:30 - 12:00	Special Session in Honour of Ken Morgan Confessions on the Joy and Pain of Combining Bench Science and Population Science - He Beat me with the Bootstrap! Carmen Sapienza (Temple University) Epigenetics of pain Jordana Bell (King's College London) Gene ancestry and descent in large Canadian pedigrees Elizabeth Thompson (University of Washington) On Ascertainment and Sampling in Statistical Genetic Analysis Shelley Bull (University of Toronto) Genetics of Complex Diseases in Minority Populations Jean MacCluer (Texas Biomedical Research Institute) Chairs: Celia Greenwood and Jinko Graham Evaluate this session	Grand Event Room A&B
12:00 - 13:30	Lunch	Sunhill Dining Room
13:30 - 15:00	Plenary Session on Neurocognitive Genetics Chair: Dan Goldowitz (University of British Columbia) Genetic architecture in autism spectrum disorder Stephen Scherer (Hospital for Sick Children) Genetics of Epilepsy Berge Minassian (The Hospital for Sick Children) Modelling Neuropsychiatric Traits in the Mouse: From QTL to QTG Dan Goldowitz (University of British Columbia) Role of the PRICKLE Genes in Neural Tube Defects in Humans Redouane Allache (Université de Montréal) Evaluate this session	Grand Event Room A&B
15:00 - 15:30	Break
15:30 - 17:00	Plenary Session on Microbiome in Health and Disease Chair: David Guttman (University of Toronto) The airway microbiome and re-thinking respiratory infectious diseases Michael Surette (McMaster University) How Inflammatory Bowel Disease Phenotype and Genotype Shape the Enteric Microbiome and Vice Versa Dan Frank (University of Colorado) Microbiome dynamics in the cystic fibrosis lung David Guttman (University of Toronto) Direct Assessment and Validation of Allele-Specific Transcription Factor Binding in the Human Genome Alicia Schiavi (McGill University) Evaluate this session	Grand Event Room A&B
17:00 - 18:30	Poster Session Sponsored by Genome Quebec Sponsored by Genome Quebec	Studios 10 and 11
18:30 - 20:30	Dinner	Sunhill Dining Room

Tuesday 1 May
Time	Session	Location
7:30 - 8:30	Breakfast	Sunhill Dining Room
8:30 - 10:00 Track 1	Rare Variant Methods Chair: Jinko Graham (Simon Fraser University) Design and Analysis of Whole Exome (Genome) Sequencing Association Studies for Detecting Rare Variants Effects Xihong Lin (Harvard University) Multiple Regression Methods for Rare Variant Analysis Celia Greenwood (McGill University) Combining p-Values from Linear and Quadratic Tests for Rare Variants Provides Robust Statistics across Genetic Models Andriy Derkach (University of Toronto) Adjusted Sequence Kernel Association Test for Rare Variants Controlling for Cryptic and Family Relatedness Karim Oualkacha (Lady Davis Institute, McGill university) Genome-Wide Patterns of Identity-by-Descent Sharing in the French Canadian Founder Population Héloïse Gauvin (Université de Montréal) Evaluate this session	Grand Event Room A&B
8:30 - 10:00 Track 2	Animal Model Session 2 Chair: Danielle Malo (McGill University) Modelling Human Lymphoblastic Leukemia in the Mouse: Mechanistic Discovery to New Clinical Trials Jayne Danska (Hospital for Sick Children, University of Toronto) Genomic Analysis of Innate Immunity Maya Saleh (McGill University) Mouse Models of Breast Cancer Sean Egan (University of Toronto) ENU-Induced Mutation in Ank1 Results in Hemolytic Anemia and Increased Susceptibility to Salmonella Typhimurium Infection Kyoko Yuki (McGill University) Evaluate this session	Amphitheatre
10:00 - 10:30	Break
10:30 - 12:00 Track 1	Epigenetics Chair: Paul Lasko (McGill University) Epigenetics of Colon Cancer: the Bad End of a Bad Diet? Carmen Sapienza (Temple University) The role of DNA methylation in human complex traits Jordana Bell (King's College London) Joint Effects of 16 Known Colorectal Cancer Risk Markers and 25(OH)D as a Function of Proximity to Vitamin D Receptor Binding Sites Linda Hiraki (Harvard School of Public Health) Genome-wide DNA Methylation Profiling of Childhood Leukemia Stephan Busche (McGill University) Normalization Method for Illumina Infinium Methylation Arrays in a Case-Control Study of Colorectal Cancer Jean Philippe Fortin (McGill University) Evaluate this session	Grand Event Room A&B
10:30 - 12:00 Track 2	Rare Diseases Session Chair: Kym Boycott (Childrens Hospital of Eastern Ontario) Structural biology of the inborn errors of metabolism proteome Wyatt Yue (University of Oxford) FORGE Canada: A Nation-Wide Effort to Identify Genes for Rare Pediatric Disorders Kym Boycott (Childrens Hospital of Eastern Ontario) Discovering New Genes for Primary Lymphoedema Pia Ostergaard (St George's University of London) Identifying Disease Genes in a Highly Consanguineous Community Eamonn Sheridan (Leeds Institute of Molecular Medicine) A Six Generation Newfoundland Family with X-Linked Progressive Hearing Loss Caused by a Novel Deletion in the SMPX Gene Nelly Abdelfatah (Memorial Universty) Evaluate this session	Amphitheatre
12:00 - 13:00	Lunch	Sunhill Dining Room
13:00 - 14:30	Plenary Session on Cancer Genetics Chair: William D. Foulkes (McGill University) Deciphering Familial Pancreas Cancer or ... How Not to Spend Your Summer Vacation Steven Gallinger (Mount Sinai Hospital) GNAQ and GNA11 Mutations in Uveal Melanoma Catherine van Raamsdonk (University of British Columbia) Germ-Line DICER1 Mutations Result in a Surprising Constellation of Phenotypes William D. Foulkes (McGill University) Tumor Microenvironment and Genetic Association with Colorectal Cancer Risk Dr. Vanya Peltekova (Ontario Institute for Cancer Research) Evaluate this session	Grand Event Room A&B
14:30 - 15:00	Break
15:00 - 16:30	Translating genetic research to improve the value of health care Sponsored by Mitacs Chair: Alex Mackenzie (Apoptosis Research Centre) A Prospective Clinical Trial to Evaluate DNA Sequencing as a Diagnostic Tool to Guide Cancer Therapy Tom Hudson (Ontario Institute for Cancer Research) How can Animal Models Help Understand Human Diseases? Philippe Gros (McGill University) Harnessing the Transformative Power of Genomics to Deliver Benefits to Canadians Cindy Bell (Genome Canada) Pharmacogenetics - making treatment safer and more effective William Newman (University of Manchester) Evaluate this session	Grand Event Room A&B
17:00 - 22:30	A Moveable Feast – An Evening of Good People, Good Food and Good Wine "Good People" - Canadian Gene Cure Foundation's Champions of Genetics Celebration Cocktail Reception from 17h-18h45 "Good Food" - Dinner 18h45-20h30 "Good Wine" - Poster Session & Desserts 20h30-22h30

Wednesday 2 May
Time	Session	Location
7:30 - 9:00	Breakfast	Sunhill Dining Room
9:00 - 11:00	Plenary Session on Computational Genomics Sponsored by Genome Canada Chair: Michael Brudno (University of Toronto) MedSavant: A Platform for Identifying Causal Variants From Disease Sequencing Studies Michael Brudno (University of Toronto) Measuring patterns of tumour evolution: computational models and biological inference Sohrab Shah (University of British Columbia) Metatranscriptomics: Towards a Functional Interrogation of Microbiomes John Parkinson (University of Toronto) Knowledge Engineering for Health Anthony Brookes (University of Leicester) Evaluate this session	Grand Event Room A&B
11:00 - 11:30	Conference Closure and Winner Announcement Conference Co-Chairs Dr. Jayne Danska and Dr. Erwin Schurr	Grand Event Room A&B